Evaprine®
Isoxsuprine Hydrochloride
Evaprine®
5 mg/mL Solution for (IM/IV) Injection
Tocolytic
Formulation
Each Ampule Contains:
| Isoxsuprine hydrochloride USP | 5 mg |
| Water for injection BP | q.s |
Indications:
Isoxsuprine is a vasodilator that also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular and uterine smooth muscle and its vasodilating action is greater on the arteries supplying skeletal muscles than on those supplying skin. Isoxsuprine also produces positive inotropic and chronotropic effects. Isoxsuprine hydrochloride has been used to arrest premature labor. It has also been given in the treatment of cerebral and peripheral vascular disease.
Dosage and Administration:
For use as a vasodilator, isoxsuprine hydrochloride is given by mouth in doses of 10 to 20 mg 3 or 4 times daily, or as prescribed by your physician. To arrest premature labor, isoxsuprine hydrochloride is given initially by intravenous infusion in doses of 200 to 500 micrograms/minute, adjusted according to the patient’s response, until control is achieved. It is now common practice to give beta agonists by syringe pump when using them to delay premature labor. Maternal blood pressure and hydration, and maternal and fetal heart rates should be monitored during the infusion. Once labor has been arrested, intramuscular injections of 10 mg are given every 3 to 8 hours for several days. Prophylaxis may be continued by mouth with 30 to 90 mg daily in divided doses.
Storage:
Store at temperatures not exceeding 30°C. Keep out of reach of children
Availability:
Box of 5 Ampules
Medical Disclaimer:
Please consult your physician for personalized medical advice. Always seek the advice of a physician or other qualified healthcare provider with any questions regarding a medical condition or treatment before undertaking a new healthcare regimen. This product brief is not an advertisement and is not intended to be a substitute for a professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it. If symptoms persist, consult your physician.
